Synthesis and Biotransformation of Some Halogenated Steroids by the Fungus Mucor plumbeus
نویسنده
چکیده
Preparation of some chloro, bromo and iodo steroids derived from testosterone and epiandrosterone is described. The biotransformation of halogenated products by fungus mucor plumbeus are preformed. Introduction of the halogen atom into the steroids moiety severely affected the biotransformation results. Keyword: Mucor plumbeus, biotransformation, steroids, 3dibromomethylene-5α-androstan-17-one. Introduction The application of enzymes as reagents is one of the fastest growing areas of research [1] . The value of this application – biotransformation – was first noticed when it helped to overcome a major problem in the synthesis of the cortical steroids by using the fungus Rhizopus arrhizus, Fig. 1. Fig. 1. The biotransformation of the dioxosteroids (hydroxyl or carbonyl) gave monohydroxylated products [3] . This has been widely observed by variety of fungi [4] . The presence of the two binding oxygen groups R. arrhizus COMe HO
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Biotransformation of some ring A and B epoxy steroids by the fungus Mucor plumbeus
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